Home 
Publications The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain
Publications The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain Terms Of Use
The reprints on our webpage are provided for non-commercial research and education use, including use for instruction and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited.
| Property | Value |
| Name | The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain |
| Description | The Rbfox family of RNA binding proteins regulates alternative splicing of many important neuronal transcripts, but its role in neuronal physiology is not clear1. We show here that central nervous system–specific deletion of the gene encoding Rbfox1 results in heightened susceptibility to spontaneous and kainic acid–induced seizures. Electrophysiological recording revealed a corresponding increase in neuronal excitability in the dentate gyrus of the knockout mice. Whole-transcriptome analyses identified multiple splicing changes in the Rbfox1−/− brain with few changes in overall transcript abundance. These splicing changes alter proteins that mediate synaptic transmission and membrane excitation. Thus, Rbfox1 directs a genetic program required in the prevention of neuronal hyperexcitation and seizures. The Rbfox1 knockout mice provide a new model to study the post-transcriptional regulation of synaptic function. |
| Filename | Nat Genet 2011 GehmanThe splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain.pdf |
| Filesize | 2.64 MB |
| Homepage |